It's official, the Lost numbers are categorized as Integer sequence A104101 in AT&T Research; click the link above to see it. What does this mean? Nothing. What does this tell us about the numbers? Nothing.
Here are some theories:
The episode number was 18 and the title was Numbers.
The numbers Hurley uses for his winning lottery are 4, 8, 15, 16, 23, and 42. The flight number that the survivors crashed on has two of those numbers - 815.
If you add all the digits of the numbers plus Hurley's worth in america ($156 mil) 4+8+1+5+1+6+2+3+4+2+1+5+6=48 which is the same number of the original survivors on the island.
If you add up the numbers, 4+8+15+16+23+42=108, and subtract that from Hurley's net worth (156-108=48), again, it equals the number of survivors.
Adding up 4+8+15+16+23 = 66 Add the digits of the PowerBall number 4+2=6 Also, read the Bible/Torah's Book of Numbers (4th book) 15 and 16 (Numbers <4> 8:15-16): 15 "After you have purified the Levites and presented them as a wave offering, they are to come to do their work at the Tent of Meeting. 16 They are the Israelites who are to be given wholly to me. I have taken them as my own in place of the firstborn, the first male offspring from every Israelite woman. The Levites were chosen by God to maintain the tabernacle in the middle of the wilderness and the different groups lived in tents surrounding it. Only the high priests were allowed to enter the tabernacle. People who were on the run for a crime could come to a Levite place for sanctuary and were spared. If they left, they could still be tried for their alleged crimes. However, once the high priest died, all of the people could leave and have their reputations restored. Could the hatch be a passage to a Pandora's Box or a Ark of the Covenant-type place?
Interesting how the transmission was picked up 16 years ago, but also how the lottery had not been won in 16 weeks...
8 & 15 ... 815 was the flight number of the place 4 people have been killed the french woman (chick) has been on the island for 16 years 42 survivors left what about the 23?
The passage from the Bible above also has something else of note: (Num 8:16) "I have taken them as my own in place of the firstborn, the first male offspring from every Israelite woman". This could be a reference to why they kidnapped Claire, i.e. in order to have her "firstborn" child.
As Hurley's friend Leonard is being dragged away at the psychiatric ward, he yells out to Hurley that the numbers open "the box." He could have been referring to the box on the island, or maybe Pandora's box...
The number of holes on a Connect Four game board is 42. (6 down, 7 across)
When in "The Hitchhikers Guide To The Galaxy" the question "What's the meaning of life" is entered into the supercomputer, the answer is 42...
Note that there are many other iterations of these numbers on the show, but I only listed the ones that could be connected (Walt needing a '4' and a 3 for a dice roll doesn't really count, for example). -Locke was crippled for 4 years -There were 4 guns in the marshall's case -Hurley's grandfather got his pacemaker 4 years ago -Sam Toomie killed himself 4 years ago -Sawyer made his "birthday wish" 4 years ago -Claire's boyfriend left her 4 months into her pregnancy, which was also 4 months ago, and the psychic had been calling Claire for 4 months to convince her to keep the baby -When Locke ties up Boone he says camp is about 4 miles due west, meaning the hatch they found is 4 miles from the plane crash site -Leonard playing Connect Four -Claire is 8 months pregnant at the time of the crash -8 people died in the shoe factory that Hurley owned -Michael was hit by the car 8 years ago -Michael had been writing to Walt for 8 years -DriveShaft was going to tour for 8 weeks -Michael worked in contstruction for 8 years -Shannon was 8 years old when her father married Boone's mother -Hurley's lottery drawing was on Channel 8 -Walt was born in August (8th month) -15 members on Danielle Rousseau's research team -15 was the number on the whiskey bottle that Sawyer and Jack's father shared -Danielle's expedition team shipwrecked 16 years ago -Danielle's distress call has been looping for 16 years -16 weeks since someone won the lottery before Hurley -16 years since Sam Toomie and Leonard heard the numbers -The flight that crashed was supposed to be 16 hours long -Jack's seat number was 23A -The reward for turning Kate in is $23,000 -There are 42 spaces on a Connect Four board (this is the only 'direct' reference to 42 on the show so far, unless it's someone's age and we don't know it yet) 8 & 15 together: -Oceanic Flight 815 -Kate robbed the bank for safety deposit box #815 -The copy machine Charlie sold was model C-815 -The arrival time of the flight was supposed to be 8:15 PM
In Michigan, the Lansing State Journal reports that 215 residents of that state used a sequence of six numbers (4, 8, 15, 16, 23 and 42) that were heavily featured in the March 2 episode of Lost.